In Aug 2009, the FDA added a warning label to many medications saying that they can cause rare cases of depression and suicidal thoughts. You absolutely should not take Bupropion if you have had a diagnosis of anorexia or seizures or if you’re allergic to Bupropion or if you take MAO-inhibitors. You can stop taking Bupropion immediately without having to wean off of it like other medicines. If that happens, stop taking the medicine and call us to let us know you stopped. Rarely, a patient will tell me that the opposite happened and they became anxious or crabby or mean. ![]() Many patients tell me that their spouses are happier and their bosses report they seem less stressed and are nicer to be around as well as more productive at work. You may quit smoking if you are taking this medicine. As a result, Bupropion is one of the components of the #1 most prescribed FDA-approved brand-name medication for weight loss, Contrave. Even back in 2001, it was shown in a study at Duke of non-depressed women trying to lose weight … that 3 times as many taking Bupropion saw success as those who were taking placebo (a fake pill). Further studies showed that it helps provide better weight loss than diet alone. However, later studies showed that it helped people quit smoking, so Bupropion has been FDA-approved to help with smoking cessation. Because the medicine improves stress and mood, it was originally invented as an anti-depressant. Dopamine and noradrenaline suppress your appetite. Stress increases cortisol and ghrelin which stimulate your appetite. This gives you more energy, suppresses your appetite, and enhances your mood. It stimulates noradrenaline, dopamine, and (less-so) serotonin receptors. If you are an emotional eater, this may be a great medicine for you. If you merely have bad eating habits, this may not be the best choice for you. ![]() In non-technical terms, Bupropion helps patients who have stress-related eating far better than those who have boredom-related eating.
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February 2023
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